To Study the Sodium Valproate Levels in Patients attending a Tertiary Care Centre

Dr. Sagar Kumar*; Dr. Madhulika Peter Samuel; Dr. Taskeen Tufail; Dr. Chandan Kumar

doi:10.64149/J.Carcinog.25.1.339-347

Authors

Dr. Sagar Kumar* Assistant Professor1*, Department of Pharmacology, Naraina Medical College & Hospital, Kanpur, Uttar Pradesh, India Author
Dr. Madhulika Peter Samuel Professor2, Department of Pharmacology, Rama Medical College Hospital and Research Centre, Uttar Pradesh, India. Author
Dr. Taskeen Tufail PGT 3rd year3, Department of Biochemistry, Nalanda Medical College and Hospital, Patna, Bihar, India Author
Dr. Chandan Kumar Senior Resident4, Department of Anesthesiology, Lord Buddha Koshi Medical College and Hospital ,Saharsa, Bihar, India. Author

DOI:

https://doi.org/10.64149/J.Carcinog.25.1.339-347

Keywords:

Sodium valproate, Drug levels, Patients, Monitoring

Abstract

Background:

Sodium valproate is commonly used in clinical practice, and maintaining appropriate drug levels is important for effective treatment and safety.

Aim:

To assess sodium valproate levels in patients receiving therapy.

Materials and Methods:

A cross-sectional study was conducted on 100 patients receiving sodium valproate. Drug levels were measured under steady-state conditions. Patients were grouped into low, normal, and high levels based on standard reference ranges. Data were analyzed using simple descriptive statistics.

Results:

Out of 100 patients, 62% had normal levels (50–100 µg/mL), 24% had low levels (<50 µg/mL), and 14% had high levels (>100 µg/mL). The mean level was 68.5 ± 17.6 µg/mL, with values ranging from 33 to 118 µg/mL.

Conclusion:

Most patients had sodium valproate levels within the normal range, but a considerable proportion showed levels outside the desired range. Monitoring drug levels can help in better management.