Sustained Release Oral Drug Delivery System

Abstract

Traditional drug delivery systems have been characterized by immediate release and repeated dosing of the drug which might lead to the risk of dose fluctuation, this raises the need for a formulation with control release that maintains a near-constant or uniform blood level. Sustain release systems are considered a wiser approach for drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of the absorption process from the gastrointestinal tract after oral administration. The basic objective of these dosage forms is to optimize the delivery of medications to achieve a measure of control on therapeutic effect in the face of uncertain fluctuation in the in vivo environment in which drug release takes place. Sustained release systems include any drug-delivery system that achieves slow release of drugs over an extended period. Sustained release also provides a promising way to decrease the side effects of the drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. The basic rationale of a sustained drug delivery system optimize the biopharmaceutical, pharmacokinetic, and pharmacodynamic properties of the drug in such a way that utility is maximized, side effects are reduced and cure of the disease is achieved. The principal goal of sustained release forms is the improvements of drug therapy assessed by the relationship between the advantages and disadvantages of the use of sustained release systems.