Impact of Chronic Obstructive Pulmonary Disease on Mortality and Morbidity in Patients with Stable Angina.
DOI:
https://doi.org/10.64149/J.Carcinog.24.10s.374-385Keywords:
COPD, stable angina, mortality, morbidity, oxidative stress, inflammationAbstract
Background: Chronic Obstructive Pulmonary Disease (COPD) is a significant comorbidity in patients with cardiovascular disease, including stable angina.
Objective: This study aimed to investigate the impact of COPD on mortality and morbidity in patients with stable angina at Jinnah Hospital Karachi, focusing on biochemical markers of oxidative stress and inflammation.
Methods: This prospective cohort study included 200 patients with stable angina, with (n=100) and without COPD (n=100), from January 2022 to December 2024. Patients were followed up for a median of 18 months for mortality and morbidity outcomes, including hospitalizations and quality of life assessed using the Seattle Angina Questionnaire (SAQ). Biochemical markers, such as malondialdehyde (MDA) and C-reactive protein (CRP), were measured to evaluate oxidative stress and inflammation.
Results: The study found that patients with stable angina and COPD had significantly higher mortality rates (15% vs 5%, p=0.02) and hospitalization rates (40% vs 20%, p=0.001) compared to those without COPD. COPD was an independent predictor of mortality (HR 2.5, 95% CI No1.2-5.1, p=0.01) and morbidity (HR 1.8, 95% CI 1.1-3.0, p=0.02). Patients with COPD also had poorer SAQ scores, indicating worse quality of life (mean score 50 vs 70, p<0.001), and elevated levels of MDA and CRP, indicating increased oxidative stress and inflammation.
Conclusion: COPD is a significant predictor of mortality and morbidity in patients with stable angina, associated with increased oxidative stress and inflammation. Early identification and management of COPD in patients with stable angina may improve outcomes.
