Biomarkers of Hope: The Effects of Exercise Intervention on Inflammatory and Metabolic Pathways in Cancer Prevention.

Abstract

BACKGROUND: The Prevalence of cancer around the world is hiking due to sedentary lifestyle and poor diet habits. The awareness related to preventive factors and other side strong evidence regarding the preventive risk factor are at to explore. The effective physical activity in relation to the biomechanical relationship concern to cancer reduction is not yet evident. So it could be hypothesized and studied that Physiotherapy and or structured exercise can regulate inflammatory response, oxidative stress and immunological function which are then further provide the cancer for help in the recovery face. OBJECTIVE: To conduct a scientific examination of know data related to biomechanical process broad down by exercise intervention based on structured exercise/Physiotherapy, its effect on adult on adult cancer prevention. METHOD: The study had followed the logistic approach by systematically scouting, following PICO format and applying PRISMA protocol. The studies between 2000 to 2025 has be explore through electronic databases. Full text English article published with mainly RCTs and Cozy Experimental study design were considered for the studies. Participants were only humans with adult categories, No gender specific. PRISMA 2020 protocol has been applied to scrounging and 12 studies were finally included for the systematic review. RESULT: The qualitative analysis of 12 studies listed on a customized data extraction table highlighted that structured exercise regiment can bring about variations in biochemical markers that can reduce the cancer risk. CONCLUSION: Based on the careful systematic review of 12 articles it can be concluded that structured exercise/Physiotherapy intervention can modulates biochemical pathways including inflammation, oxidative stress, metabolic and antioxidant capacity; leading to the prevention or postponing the cancer