A Review on Synthesis and Pharmacological Activity of Benzazepine

Abstract

A class of heterocyclic chemicals known as benzazepine derivatives has a variety of pharmacological properties, including as antidepressant, antipsychotic, anxiolytic, and cardiovascular actions. The several synthetic pathways, structure-activity connections, and biological activities of benzazepine derivatives are highlighted in this review, which offers a thorough overview of their synthesis and pharmacological activity. We go over the numerous synthetic techniques utilized to build the azepine ring and add different substituents, such as cyclization processes, electrophilic aromatic substitution, and metal-catalyzed cross-coupling events. We also look at the pharmacological characteristics of derivatives of benzazepine, including their in vivo and in vitro activity, receptor binding affinities, and modes of action. In addition to highlighting the derivatives' potential as therapeutic agents and outlining upcoming investigations objectives, In-depth knowledge of the synthesis and pharmacological effects of benzazepine derivatives is the aim of this investigation