Formulation And Evaluation Of Liquisolid Compact For Pazopanib

Abstract

Objective: The aim of the present investigation was to develop a liquisolid compacts to enhance the oral absorption of Pazopanibe by improving dissolution rate. Experimental work: the solubility of pazopanib in various liquid vehicles was determined. Liquisolid compacts were prepared using polyethylene glycol as a solvent, microcrystalline cellulose as carrier materials and silica as coating material. The interaction between drug and excipients were characterized by FTIR. The powder characteristics were evaluated by different flow parameters to comply with pharmacopoeial limits. The dissolution studies for liquisolid compacts and conventional formulations were carried out. Results and Discussion: liquisolid compacts showed significant higher drug release rates than conventional tablets. formulation F3 showed superior dissolution and are more effective carrier materials for liquid adsorption. Conclusion: it was concluded that liquisolid compacts would be a promising drug delivery system for poorly water-soluble drugs by the oral route..