Formulation and Evaluation of Canagliflozin-Loaded Nanostructured Lipid Carries

Abstract

Aim  of  this  research  work is  to  develop  and  evaluate  Canagliflozin-loaded  Nanostructured  Lipid  Carriers  (NLCs)  to improve the drug’s solubility, oral bioavailability, and therapeutic efficacy in type 2 diabetes mellitus.

NLCs  was  formulated  by  using  suitable  solid  and  liquid  lipidswith  surfactants,  followed  by  characterization  through particle  size,  zeta  potential,  entrapment  efficiency, in  vitrodrug release  profile,  TEM,  and  stability  evaluation  of  the optimized  formulation.  Canagliflozin-loaded  NLCs  were  prepared  using  a  high-speed  homogenization  method  followed by  ultrasonication. The  prepared  NLCs  were  evaluated  for  particle  size,  zeta  potential,  drug  content,  entrapment efficiency, and in vitro drug release.TEM analysis was performed to study morphology. Stability studies were carried out in compliance with ICH guidelines.

FTIR study  was conducted for identifying  functional  groups and drug-excipient compatibility study and  found that  they are compatible with each other. The in-vitro drug release profile confirmed improved release characteristics. The optimized formulation  (CF3)  exhibited  favourable  particle  size  of  305  nm,  high  drug  content  of  96.23  %,  and  high  entrapment efficiency  of  94.56%.  TEM  images  confirmed  smooth  and  spherical  particle  morphology,  indicating  successful  NLC formation.  Stability  studies  shown  good  physical  stability  and  there  were  no  significant  changes  in  the  physic-chemical properties  of  formulation.  So  it  was  concluded  that,  the  Canagliflozin-loaded  NLCs  are  potential  and  effective  drug delivery system.