Formulation and Development of HA BSA Coated NLC Containing Fisetin and Flavokawain A for the Treatment of Lung Carcinoma

Abstract

Lung carcinoma continues to be a predominant cause of cancer-related mortality globally.  This paper presents an innovative nano-delivery system utilizing hyaluronic acid (HA) and bovine serum albumin (BSA)-coated nanostructured lipid carriers (NLCs) infused with fisetin and flavokawain A (FKA) for targeted lung cancer treatment.  We offer an extensive literature review, outline a theoretical formulation and characterization approach, and present synthetic data demonstrating the improved physicochemical properties, prolonged release, and synergistic anticancer efficacy of the dual-loaded HA-BSA NLCs.  The study emphasizes the potential of integrating natural flavonoids with HA-BSA NLCs to enhance delivery to CD44-expressing lung cancer cells and provides valuable insights for forthcoming experimental investigations.