Design And Optimization Of Natural Polymer Based Floating Tablets Of Famotidine
DOI:
https://doi.org/10.64149/J.Carcinog.24.8s.150-161Keywords:
Famotidine, floating tablets, gastro-retentive drug delivery, natural polymers,oyster mushroom powder,treated ghee-residueAbstract
Background:Famotidine, a histamine H₂-receptor antagonist, suffers from low oral bioavailability and short half-life, necessitating frequent dosing. Developing floating controlled-release tablets can enhance gastric retention, improve bioavailability, and sustain drug release.
Objective:This study aimed to design, optimize, and evaluate floating Famotidine tablets using natural polymerstreated ghee-residue and oyster mushroom powderas novel excipients.
Methods:Floating tablets were prepared by direct compression employing a 3² factorial design, with polymer concentration and gas-generating agent concentration as independent variables. Tablets were assessed for pre- and post-compression parameters, buoyancy, swelling index, drug content, dissolution profile, release kinetics, FTIR compatibility, and stability.
Results:All formulations exhibited acceptable physicochemical properties, buoyancy for >15 hours, and compliance with pharmacopeial standards. Dissolution studies revealed Zero-order release kinetics, with the Korsmeyer–Peppas model indicating non-Fickian diffusion. Treated ghee-residue formulations showed more sustained drug release compared to oyster mushroom powder. Among all, formulation F3 (Famotidine: ghee-residue at 1:1.5 ratio) demonstrated optimal floating lag time (1.59 min), prolonged release (12 h), and stable performance under accelerated conditions.
Conclusion:Treated ghee-residue proved superior to oyster mushroom powder in sustaining Famotidine release, highlighting its potential as a cost-effective, sustainable, and efficient natural polymer for gastro-retentive formulations
