Synergistic Interplay of Dopaminergic and Serotonergic Agents with Citral in Mitigating Motor Deficits: A Rodent Model Evaluation

Abstract

Dopaminergic and serotonergic systems play vital roles in motor function, and imbalances in these systems can lead to motor deficits. Dopamine, primarily involved in movement initiation and coordination, is often reduced in conditions like Parkinson's disease, causing tremors and rigidity. Serotonin, while also impacting motor control, is more broadly involved in regulating mood, arousal, and motivation, all of which can indirectly affect motor performance. Interactions between these neurotransmitter systems are complex, with serotonergic neurons modulating dopaminergic activity and vice versa. In present study an attempt was made to study the Effect of Haloperidol, Citral, Serotonin analogue antagonist/antagonist on Citral, induced cataleptic effect, Dopamine analogue antagonist/antagonist on cataleptic effect of citral in Actophotometer test. Citral (75 mg/kg) affected the locomotor activity in rats in comparison to control group. Selective 5-HT2A receptor antagonist Glemanserin (MDL-11,939) at low dose (1 mg/kg) 5-HT2A/2C antagonist ritanserin at high dose (10 mg/kg) with citral potentiate inhibition of locomotor activity with citral in  rats

Ipsapirone (5 mg/kg) a selective 5-HT1A receptor agonist and RU 24969 is a 5-HT1A and 5-HT1B receptor agonist restore Locomotor activity in  rats caused by citral.  Ropinirole (5 mg/kg) and Pramipexole (5 mg/kg) Dopamine analogue agonist reverse the Citral induced inhibition of locomotor activity and increases the Locomotor count.