Effect of fluoride-induced toxicity on the rat nephrotoxicity and a therapeutic effect of Ocimum sanctum (Tulsi) leaf extract

Abstract

Fluoride naturally occurs in soil, plants, animals, and water. A minimum amount of Fluoride is beneficial for the body, but an excessive amount can damage many organs, including the kidneys, liver, and brain. Chronic exposure to high levels of Fluoride causes oxidative stress, cellular damage, and histopathological damage. Experimental Animal: Take the Adult albino rats (150gm to 200gm) kept them in clean cage with suitable temperature and environment with proper food diet Most studies focused only in fluoride toxicity few research explore the protective and antioxidant effect of Ocimum Sanctum (Tulsi) leaf extract on Fluoride toxicity induce in rat model This show the biochemical, histopathological, body weight changes in animal model. To evaluate the protective and therapeutic potential of Tulsi (Ocimum Sanctum) leaf extract against the Toxicity of Fluoride in albino rats by analyzing Biochemical, Phytochemical, and histopathological parameters To study and analyze the change in the Hematology (blood) parameter, biochemical enzymes, and antioxidant enzymes on inducing Fluoride toxicity, and then study the protective and detoxifying effect of  Tulsi leaf extract against toxicity on the param Toxicity of fluoride reduces the level of urea, creatinine, and liver enzymes, indicating severe oxidative and cellular damage, and also damages the kidney structure, function, and many tissues. This shows a chronic effect on the kidney as well as enzymes. Study concludes that Tulsi leaf extract effectively alleviates Fluoride toxicity by enhancing defense and protective integrity, so it is considered a natural therapeutic agent