Anti-Ulcerogenic Potential of Phyllanthus emblica Seed Extract: A Preclinical Study in the Context of Formulation Science

Abstract

Several factors can contribute to the development of ulcers in humans, including stress, chronic use of anti-inflammatory drugs, and other unidentified causes. The underlying mechanism involves an imbalance between aggressive factors and the maintenance of mucosal integrity, which relies on the body's natural defense mechanisms. Traditional healers have long relied on various native plants and their derivatives to treat peptic ulcers. In India, Phyllanthus emblica, an evergreen tree, is commonly used by traditional practitioners for gastric ulcer healing. This study aimed to evaluate the in-vitro antiulcer activity of Phyllanthus emblica seed aqueous extract (AE). The anti-ulcer activities were assessed using various doses of the aqueous extract (100 mg, 500 mg, 1000 mg, and 1500 mg) through an in-vitro method known as the H+/K+ - ATPase inhibition activity method. The extract exhibited a significant decrease in acid neutralizing capacity (ANC) compared to the standard Aluminum hydroxide + Magnesium hydroxide (500 mg). The antiulcer properties of Phyllanthus emblica seed powder have been extensively studied, highlighting the efficacy of its active constituents.