A Review On: Force Degradation Studies & Stability Indicating RP-HPLC Methods for Selected Antiemetic Drug

Abstract

The development of analytical procedures that indicate stability is crucial for pharmaceutical goods because it ensures their quality, safety, and effectiveness throughout their shelf life.  Because of its great sensitivity, repeatability, and capacity to resolve complicated mixtures, reverse-phase high-performance liquid chromatography (RP-HPLC) has become the most used analytical technique.Antiemetic drugs such as hyoscine N-butyl bromide (HBB), promethazine hydrochloride, and paracetamol—often used in combination with antiemetics—require robust analytical procedures to monitor degradation pathways and assess stability under stress conditions. Force degradation studies, including hydrolytic, oxidative, photolytic, and thermal stress testing, are essential in evaluating the stability profile of these drugs and in establishing reliable stability-indicating methods in accordance with ICH guidelines.Development and validation of RP-HPLC techniques for specific antiemetic medicines are now subject to regulatory restrictions and recommendations, which this paper comprehensively summarizes.  The significance of forced degradation research in specificity testing, product identification, and degradation mechanism elucidation is highlighted.  In addition, the study emphasizes the use of RP-HPLC technologies for regular analysis of pharmaceutical formulations and bulk medicines, quality control, and pharmacokinetic estimates.  This review seeks to optimize stability-indicating RP-HPLC methods for antiemetic agents by combining recent advances and regulatory perspectives. The ultimate goal is to improve therapeutic reliability and comply with global regulatory standards.