Study Of Microvessel Density (MVD), Estrogen Receptor (ER) And Progesterone Receptor (PR) Expression In Correlation With Modified Bloom Richardson (MBR) Grading As Prognostic Indicators In Breast Carcinoma

Abstract

Introduction: Globally, breast cancer is the most prevalent cancer to be diagnosed in women.In India, it makes around 5–8% of all cancer cases.  Numerous pathological and clinical prognostic indicators are important in the treatment of breast cancer.

Aim: To study Microvessel density (MVD), Estrogen receptor (ER) and Progesterone receptor (PR) in correlation with Modified Bloom Richardson grading as prognostic indicators in breast carcinoma.

Materials & Methods: The study was designed as a cross-sectional observational study and was conducted in the Department of Pathology at Gandhi HospitalSecunderabad. The study duration was from October 2022 to March 2024, and a total of 40 patients were included as the sample size.

Result: In our study ER expression showed no significant association with the number of lymph nodes involved, with 17ER-positive (59%) and 7ER-negative (64%) cases in the node-negative group, and similar distributions across 1–3, 4–9, and ≥10 nodes (p = 0.7). In contrast, lymphovascular invasion (LVI) was significantly associated with ER status. Among 13 cases with LVI, 5 were ER-positive (18%) and 8 ER-negative (72%), while in 27 cases without LVI, 24 were ER-positive (82%) and 3 ER-negative (28%) (p = 0.0008)

Conclusion: We found that the majority of the 40 patients with breast cancer were between the ages of 41 and 50.  While Grade 1 tumors frequently had low microvessel density (MVD), Grade 2 and Grade 3 tumors tended to have high MVD.