Disinfection potential of 1% CHX Gel Compared to 10% Doxycycline for Titanium Implants Infected with P. gingivalis

Abstract

Background: Chlorhexidine is among various antimicrobial agents assessed for managing peri-implantitis at different concentrations; however, it is considered ineffective at concentrations of 0.05-2% against P. gingivalis. Doxycycline has also been reported to have short-term benefits in cases of peri-implantitis. However, existing literature data is scarce comparing these two agents.

Aim: The study was conducted with an aim to assess and compare the disinfection potential of 1% CHX Gel compared to 10% Doxycycline for sandblasted acid‑etched Titanium Implants Infected with P. gingivalis.

Methods: The study assessed sandblasted acid‑etched titanium implants that were divided into two groups, namely Group I and II. Both groups were further subdivided into three subgroups, labeled A-I, B-I, and C-I, and A-II, B-II, and C-II. All the implant surfaces in both groups were disinfected with P. gingivalis. Group I implants were managed with 1% chlorhexidine, and Group II with 10% doxycycline gel. Following decontamination, residual counts of viable P. gingivalis were evaluated using from culture method.

Results: The study results showed that at baseline, mean values from Groups I and II were 110,000,000 CFU (colony-forming unit). On day 1, mean CFU values from Groups B-I and A-I were 0 and 3289.65 CFUs, respectively, whereas on days 3 and 7, mean values in groups A-I, C-I, and B-II and C-II were 0 colony-forming units.

Conclusion: The present study concludes that multiple applications of 10% doxycycline gel and 1% chlorhexidine gel have high efficacy for disinfection of sandblasted acid‑etched titanium implants infected with P. gingivalis and thus, both these gels can be considered as cost-effective treatment options for management of peri-implantitis.