Evaluation of the Efficacy and Accuracy of a Marker Clip System in Ultrasound-Guided Core Needle Biopsy for Breast Cancer Localization Before and After Neoadjuvant Chemotherapy

Abstract

Background: Breast cancer is a predominant cause of death in women, and precise tumor localization is essential for efficient therapy. Intramammary marker clips are increasingly employed to improve accuracy in neoadjuvant chemotherapy and surgical procedures.

Objective: The objective of this study is to examine the efficacy and reliability of intramammary marker clips for accurate tumor localization, while analyzing their stability, safety, and influence on treatment.

Methods: A retrospective analysis was performed on 94 individuals receiving neoadjuvant treatment for invasive breast cancer. Marker clips were inserted using ultrasound-guided core needle biopsy and then monitored with digital breast tomosynthesis and sonography. The principal outcomes encompassed clip stability, displacement rates, and their impact on pathological evaluation and surgical planning.

Results: Digital breast tomosynthesis exhibited enhanced accuracy in marker clip localization relative to sonography, accompanied by markedly reduced dislocation rates. No significant clip migration occurred during treatment, and no procedural problems were noted. Furthermore, the clips did not obstruct pathological assessment or surgical interventions, hence facilitating uninterrupted therapy oversight.

Conclusion: The results confirm that intramammary marker clips are an effective instrument for tumor localization, enhancing neoadjuvant chemotherapy evaluation and increasing surgical results. Their stability and accuracy increase breast cancer care techniques, facilitating their incorporation into mainstream clinical practice