Oral Verruciform Xanthoma - Case report and review of a clinical diagnostic enigma

Abstract

Oral verruciform xanthoma is a rare benign lesion characterized by the presence of foamy histiocytes.This case report presents a verruciform xanthoma on the mandibular alveolar ridge in a 45-year-old male, presenting as a painless, papillomatous growth. Histopathology revealed hyperplastic epithelium with foamy histiocytes, confirmed by CD68 positivity. Surgical excision was curative, with no recurrence at 6 months.  Oral Verruciform xanthoma mimics malignant or premalignant conditions, demanding histopathological confirmation. This case highlights the importance of multimodal diagnosis along with a review of all reported cases in the last decade