Formulation and Evaluation of Solid Lipid Nanoparticle for Enhanced Solubility and Bioavailability of Poorly Soluble Efinaconazole Drug

Abstract

The objective of present investigation was to prepare & evaluate solid lipid nanoparticle (SLN) For Enhanced Solubility and Bioavailability of Poorly Soluble Efinaconazole Drug. SLN were formulated by High-shear hot homogenization and ultra-sonication method using stearic acid, Glyceryl monostearate, palmitic acid, and surfactants (1% and 2%). All the formulation was subjected to particle size, particle size distribution, zeta potential, scanning electron microscopy, crystallinity study by DSC and in-vitro release studies. It has been observed that, the high lipid concentration containing formulation have higher entrapment as compare to other two formulations.  The SLN- dispersion shows 77.9±0.55% entrapment & zeta potential of the formulation was -31.1 which indicates the stability of formulation. The In-Vitro drug release rate of gel was evaluated using Modified franz diffusion cell containing dialysis membrane with phosphate buffer pH 7.4 as the receptor medium. It was concluded that the Efinaconazole loaded SLN formulation containing stearic acid, Glyceryl monostearate, palmitic acid, and surfactants (1% and 2%) shows much better result for Enhanced Solubility and Bioavailability of Poorly Soluble Efinaconazole Drug.