Natural Inhibitors of Cell Proliferation: Role of Plant Bioactives in Regulating Angiogenesis and Apoptosis

Abstract

Traditional medicine has been trying to find a cure for cancer for hundreds of years. It is a complicated disease that has affected people all over the world. Genetics, lifestyle choices, and the environment are just a few of the many things that might cause cancer. The Folklore who are affected prefer traditional medicine to chemotherapy and radiotherapy, which have many adverse effects. Medicinal plants, abundant in bioactive compounds, present a viable approach for cancer treatment and prevention. These natural substances have many different anticancer effects, such as killing cancer cells, causing apoptosis, stopping the cell cycle, and stopping angiogenesis and metastasis. Numerous plant-derived substances have demonstrated considerable efficacy in preclinical research and clinical trials. Modern medicine has come a long way, but researchers are still looking at how plant-based remedies could be able to work with or even replace traditional treatments. Traditional herbal or Ayurvedic treatments might mitigate physiological alterations without inducing toxicological consequences. Medicinal plants can improve patient outcomes and complement conventional therapy by targeting various molecular pathways involved in the onset and advancement of cancer. To optimize their therapeutic efficacy, further research is required to elucidate their mechanisms of action, establish optimal doses, and mitigate any potential adverse effects. This review examines the mechanisms of action of many medicinal plants and their bioactive chemicals, emphasizing their potential to target certain cancer pathways. By using the force of nature to find innovative ways to stop and treat cancer