Hormones and Cytokines in Relation with Overweight and Hyperglycemia in PCO Patients

Abstract

Polycystic ovarian syndrome (PCO) is one of the most common endocrine disorders of females. It is frequently accompanying by insulin resistance, hyperandrogenima and hyperlipidemia, that lead to severe consequence in the patients. In the current research, we aimed to evaluate hormones (FSH, LH, total and free testosterone, prolactin, anti-Mullerian, progesterone, estradiol) and cytokines (serum levels of TNF-α, IL-1b, IL-6, IL-8 and IL-10) in relation with overweight and hyperglycemia in PCO patients. Blood samples were collected from one hundred married infertile PCO women (23.30±4.659 years) visiting Al-Shatra and Bint AL-Hoda hospitals in Thi-Qar governorate- Iraq, who diagnosed according to Rotterdam criteria. Blood samples were also collected from 50 healthy, age matched, non-pregnant with regular menstrual cycle, to serve as control. The patients of PCO were classified into four groups according to BMI and fasting serum glucose level, (normal weight nondiabetic patients [BMI: 22.03±4.82 kg/m2 and serum glucose: 99.45±10.62 mg/dl], normal weight diabetic patients (BMI: 22.58±4.74 kg/m2 and serum glucose: 128.93±16.34 mg/dl), overweight non-diabetic patients (BMI: 30.27±5.22 kg/m2 and serum glucose: 100.45±12.54 mg/dl) and overweight diabetic patients (BMI: 34±6.28 kg/m2 and serum glucose: 130.88±18.22 mg/dl) compared with healthy control (BMI: 22.84±4.63kg/m2 and serum glucose: 96.14±10.23 mg/dl).