The Influence of Lyophilized Platelet-Rich Fibrin in The Treatment of Periodontal Intra-Bony Defects (A Randomized Clinical Trial)

Abstract

Objectives: The current research aimed to evaluate the influence of lyophilized platelet-rich fibrin (Ly-PRF) in the management of periodontal intra-bony deformities. Patients and Methods: 36 intra-bony deformities (IBD) in 36 individuals with stage III periodontitis of both genders participated in the present randomized controlled prospective clinical investigation. The participants were randomly received either OFD alone [group I (control, n=18)] or OFD with combination of Ly-PRF [group II (test, n=18)]. All patients were evaluated clinically at; baseline, 3- and 6-month utilizing plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL). Radiographic evaluation of the marginal bone level (MBL) and defect depth (DD) was evaluated at baseline and after 6-month. Results: The two treatment regimens lead to statistically significant PPD decreases and CAL gain from baseline to 6 months; the decrease in PPD and the gain in CAL were significantly greater in group II in comparison to group I. Radiographically, the mean value of MBL for the two groups showed additional marginal bone loss at 6 months; this loss was non-significant between the groups. The mean DD for both groups displayed statistically significant decrease from baseline values to 6-month; the decrease in DD was significantly greater in group II in comparison to group- I. Conclusions: Given the constraints of this research, it may be concluded that the adjunctive utilize of Ly-PRF in the surgical management of periodontal intra-bony deformities exhibited promising results on the clinical and radiographic results regarding to the PPD decrease, CAL gain as well as DD reduction.