Clinical Outcomes of Cervical Cancer Patients Treated with Surgery and Concurrent Chemoradiation Therapy in CMH, Dhaka

Nazma Siddiquee, SM Rokonuzzaman, Shamima Yasmin, Farhana Jannat, Reshma Sharmin

doi:10.64149/J.Carcinog.25.1.184-191

Authors

Nazma Siddiquee, SM Rokonuzzaman, Shamima Yasmin, Farhana Jannat, Reshma Sharmin Author

DOI:

https://doi.org/10.64149/J.Carcinog.25.1.184-191

Keywords:

Cervical cancer, chemoradiation, radical hysterectomy, survival outcomes, recurrence, HPV vaccination, Early detection.

Abstract

Background: Cervical cancer is a leading cause of cancer-related death among women, particularly in developing countries. Early-stage disease can often be cured with surgery or chemoradiotherapy, while advanced stages require combined treatment approaches. Outcomes vary depending on disease characteristics, patient factors, and healthcare resources. Limited data exist in Bangladesh regarding treatment responses, survival, and complications. This study aims to evaluate the clinical outcomes of cervical cancer patients undergoing radical hysterectomy and chemoradiation therapy in a tertiary care military hospital.

Methods: This retrospective cohort study at Combined Military Hospital, Dhaka, Bangladesh (2015–2022) included 192 cervical cancer patients treated with radical hysterectomy, concurrent chemoradiation, or both. Data on demographics, tumor characteristics, treatment, and follow-up outcomes were collected. Primary outcomes were 5-year overall and disease-free survival, while secondary outcomes included recurrence and post-treatment complications. Survival and recurrence analyses were performed using chi-square tests and Cox regression, with p < 0.05 considered significant.

Results: Among 192 cervical cancer patients, most were middle-aged with squamous cell carcinoma and stage II disease. Treatments included surgery, CCRT, or both, with 35% experiencing complications. Five-year survival was 71.9%, highest after surgery alone, and recurrence occurred in 18%, with advanced stage, adenocarcinoma, and positive lymph nodes predicting higher risk.

Conclusion: Survival and recurrence in cervical cancer are strongly influenced by disease stage and treatment type. Surgery is most effective in early stages, while CCRT is essential for advanced disease. Delayed detection highlights the need for early screening, HPV vaccination, multidisciplinary care, and a national cancer registry in Bangladesh.