Clinical Intervention of Unani Medicine in case of Infertility (Uqr) due to Polycystic Ovarian Disease (Marz-e-AkhysKusytur Rahem)-A Systematic Clinical & Meta Analysis

Abstract

Infertility (Uqr) is a foremost reproductive healthiness issue distressing nearly 10–15% of couples worldwide, and Polycystic Ovarian Disease is one of the most common causes of anovulatory infertility in women of reproductive age. PCOD is associated with hormonal imbalance, irregular menstruation, obesity, and hirsutism, leading to ovulatory dysfunction. According to Unani medicine, infertility due to PCOD is described under Ihtibas-al-Tams (retention or suppression of menses) and is primarily caused by Sue Mizaj Barid Balghami (cold and phlegmatic temperament) that leads to uterine coldness, sluggishness, and impaired ovarian function. To evaluate the clinical efficacy and safety of Unani formulations in improving ovulation, menstrual regularity, and conception rates in patients suffering from infertility due to PCOD. Treatment was administered for three consecutive menstrual cycles, and patients were monitored for ovulation by ultrasonography (USG), along with hormonal assays and clinical symptom assessment.Most patients belonged to the 21–30-year age group (73.3%), and the highest incidence of infertility was observed among those with 4–6 years of married life. In Group A, 13 out of 15 patients (86.67%) exhibited ovulation with complete normalization of menstrual cycles, and 7 patients conceived during the study period. Group B showed ovulation in 10 patients (66.67%), with 4 conceptions. Improvement in menstrual regularity was achieved in all cases of both groups, while symptoms like hirsutism and obesity showed partial improvement. No adverse effects were reported in either group, confirming the safety and tolerability of the treatment. The study establishes that Unani formulations are effective in treating infertility due to PCOD, particularly by inducing ovulation and restoring menstrual regularity. The Group A formulation showed superior efficacy, likely due to its emmenagogue, aphrodisiac, deobstruent, and uterine tonic properties, which align with the Unani principles of Taqwiyat-e-Rahem (uterine tonicity) and E‘tidal-e-Mizaj (restoration of temperamental balance). These results support the traditional Unani approach as a natural, holistic, and cost-effective alternative to conventional hormonal therapies..