Synthesis, Characterization and In Vitro Anti-Oxidant Activity of Novel Piperazine Derivatives

Abstract

The objective of this work was to conjugate naphthalene and piperazine nucleuses for designing and synthesis of new heterocyclic compounds. The compounds were also evaluated for their antioxidant action using DPPH and Phosphomolybdenum assay protocols. The synthesized compounds 6a-j were obtained in yield of 64-78% and were soluble in chloroform. the presence of carbon side chain on piperazine ring (1-4 carbon) improved the anti-oxidant potential (6b-6e) whereas increasing the chain length or presence of aromatic substituents reduced the antioxidant action. The results of the antioxidant activity study led us to conclude that linking the two nucleuses indeed proved beneficial for the activity as the compounds were able to inhibit the radical generation in significantly lower doses