Advancing Metallo pharmaceuticals Structural, Spectroscopic, and Bio-functional Studies of a Copper (II)–Curcumin Hybrid

Abstract

By condensing 1,7-bis (4-hydroxyl-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (Curcumin) with thiosemicarbazide hydrochloride, a schiff base ligand (L) generated from curcumin was produced. Multiple spectroscopic methods, including UV-Vis, FT-IR, XRD, and TGA, were used to analyze the synthesized copper complex of ligand [L]. We know that the copper complex is not an electrolyte because of its molar conductance value. Up to 600°C, the copper complex remained stable, according to thermogravimetric research. Microanalytical measurements corroborated the (1:1) copper:ligand stoichiometry of the produced Cu complex, and UV-Vis spectral studies assigned the square planar shape to the Cu (II) ions. The antibacterial and antioxidant activities of the ligand and its copper complex were studied, and the findings revealed that the Cu (II) complex exhibited significantly stronger actions than the ligand alone. Results from in vitro cytotoxicity tests on human breast cancer cell lines (MCF-7) indicate that the synthesized compounds have moderate to good cytotoxic capability.