Assessment Of Hepatitis B Vaccination Coverage And Antibody Response In Healthcare Workers
DOI:
https://doi.org/10.64149/J.Carcinog.24.9s.72-77Keywords:
Assessment, Hepatitis B, Vaccination, Antibody Response, Healthcare WorkersAbstract
Background: Hepatitis B virus (HBV) infection poses a serious occupational risk to healthcare workers (HCWs), despite the availability of effective vaccines. Assessing vaccination coverage and immune protection among HCWs is essential to guide preventive strategies.
Material and Methods: A cross-sectional study was conducted among 200 HCWs in a tertiary care hospital. Data on demographics, vaccination history, and occupational exposure were collected using a structured questionnaire. Serum samples were tested for HBsAg and quantitative anti-HBs antibody titers using ELISA. Titers ≥10 mIU/mL were considered protective.
Results: Among 200 HCWs, 28% were fully vaccinated, 42% partially vaccinated, and 30% unvaccinated. Protective anti-HBs titers were observed in 93% of fully vaccinated HCWs, 19% of partially vaccinated HCWs, and none of the unvaccinated group. Seroprotection was significantly associated with completion of the three-dose schedule (p<0.05).
Conclusion: Despite universal recommendations, HBV vaccination coverage among HCWs remains suboptimal, with large proportions partially vaccinated or unvaccinated. Ensuring complete vaccination, post-vaccination serological testing, and institutional policies for mandatory HBV immunization are crucial to protect HCWs from occupational HBV transmission.
