Defining the role of polyamines in colon carcinogenesis using mouse models

Natalia A Ignatenko1, Eugene W Gerner1, David G Besselsen2
1Department of Cell Biology and Anatomy, Arizona Cancer Center, 1515 N. Campbell Ave., Tucson, Arizona 85724, USA.
2University Animal Care, University of Arizona Central Animal Facility, Room 116, 1127 E Lowell St, Tucson, AZ 85721-0101, USA.
DOI: 10.4103/1477-3163.79673


Genetics and diet are both considered important risk determinants for colorectal cancer, a leading cause of death in the US and worldwide. Genetically engineered mouse (GEM) models have made a significant contribution to the characterization of colorectal cancer risk factors. Reliable, reproducible, and clinically relevant animal models help in the identification of the molecular events associated with disease progression and in the development of effictive treatment strategies. This review is focused on the use of mouse models for studying the role of polyamines in colon carcinogenesis. We describe how the available mouse models of colon cancer such as the multiple intestinal neoplasia (Min) mice and knockout genetic models facilitate understanding of the role of polyamines in colon carcinogenesis and help in the development of a rational strategy for colon cancer chemoprevention.

Keywords: Apc Min/+ , DFMO, mouse models, NSAIDs, polyamines, SLC3A2