Prevalence of Histopathological Changes in Cholelithiasis cases

Abstract

Introduction: The gall bladder is a small hollow organ, situated in the right upper quadrant of the abdomen. It plays a significant role of biliary system in body. The gall bladder stores the bile produced by the liver. It is responsible for almost 95% of cases of biliary tract disease. The prevalence varies according to ethnicity, age and gender. lifestyle of people changes including their dietary intake of unhealthy foods high in fat, lack of exercise, obesity and various factors.

Aim & Objective: To Review the Prevalence of histopathological changes in cholelithiasis cases and compare with different age groups and gender.

Method and Material: The cross-sectional study was done in department of Pathology, Anatomy and Surgery.  A total of 140 specimens were taken from gallbladders after cholecystectomy. Inclusion Criteria for specimen were cholecystectomy specimens with cholecystitis and cholelithiasis cases between age groups between 18-60 years.

Results: All mucosal changes were significantly more common in females than in males. Chronic cholecystitis was the most common disease, particularly in women. Rokitansky Aschoff Sinuses were more in females than males and muscular hypertrophy were relatively common in both females and male.

Conclusion: Cholecystectomy is a common surgical procedure that is crucial for gallbladder disease in the worldwide. All histopathological changes were significantly more common in females than in males.