Artificial Sweetener-Sweetened Beverages as a Biomolecular Carcinogenic Agent: Experimental Evidence from 147 Cancer Patients
DOI:
https://doi.org/10.64149/J.Carcinog.24.3s.321-331Keywords:
Artificial sweeteners; Sugary beverages; Carcinogenesis; Oncogenic mutations; p53; KRAS; Ki-67Abstract
Background: Artificial sweetener–containing sugary beverages (AS-SBs) are ubiquitous; their biomolecular impact on carcinogenesis remains debated.
Objective: To experimentally investigate the mutagenic effects of daily AS-SB intake on cancer cell mutation profiles and patient habits in Indonesian cities.
Methods: We enrolled 147 cancer patients (ages 8–50) with daily consumption of AS-SBs, across Ambon, Makassar, Ternate, and Manado between 12 January 2024 and March 2025. Laboratory assays analyzed mutational profiles of cancer cells; structured interviews captured consumption patterns.
Results: AS-SB intake significantly increased oncogenic mutation markers and cell proliferation versus controls. Behavioral and molecular data correlated with dosage and duration.
Conclusions: Frequent intake of AS-SBs may enhance carcinogenic cell mutation and proliferation in young–middle-aged cancer patients in Indonesia.
