Citrulline as a alternative for the Arginine in stimulating Growth Hormone

Abstract

Objective: children attending the specialized centre for endocrinology and diabetes and the children hospital in medical city who suffer from short stature.

Subjects And Methodes: human Growth hormone (GH) is a hormone that is essential for normal growth and development in children. It promotes proper linear bone growth from birth through puberty. There are many methods for stimulation growth hormone, the major method is the by glucagon IM and arginine infusions. This test is very important for assessment pituitary gland in children and adult for the produce and secretion growthhormone.40 child suffer short stature fromattending the specialized centre for endocrinology and diabetes and the children hospital in medical city. Citrulline it is amino acid that is used today in medicine as a cure for hypotonic in adult and blood pressure reduce inchildren.citrulline convert to arginine in the urea cycle and body. In this research used citrulline for the stimulation growth hormone alternative for arginine children and camper with stimulation by glucagon.

Setting: This study was performed during November 2023to February 2024.subject were selected from among the were diagnosed by the growth scale and to know the   value of the growth hormone.When reviewing,the child must be fasting the basil blood is drawn and then the child will be injection by glucagon 0.03 mg\kg and then after 2 hours,the secondwithdrawal is done to see the extent of stimulation. after a period of two weeks to a month, the process is repeated for the same child using the citrulline oral at 0.33 gm\kg.And measured the s. glucose, s. creatinine,blood pressure and BMI. Aim of this study: Test the citrulline as a substitute for arginine in a growth hormone stimulation test and find out how efficient it is with stimulation compered to glucagon.

Result: The results showed for 40 children that the highest rate of stimulation with glucagon is 5.662 ng\ml from 0.965 ng\ml as a basil and the highest stimulating rate with citrulline is 3.258 ng\ml from1.036 ng\ml as a basil, which means that there is a significant difference between the two cases and that the glucagon Best as a catalyst of citrulline. The ratio of the efficiency of the citrulline compared to the glucagon is 57.7%.

Conciustion: This study has been proven the citrulline can be used as stimulation for growth hormone with the need for other research to know the optimal dose and appropriate time for the highest stimulation.