Endometrial Carcinoma With Prominent Squamous Differentiation In A Postmenopausal Woman: A Case Report

Abstract

Background: Endometrial Carcinoma is the most common gynecological malignancy in the postmenopausal age group. Squamous differentiation is an uncommon histological variant that may pose diagnostic challenges, particularly in distinguishing it from primary cervical malignancy. Case Presentation: We report a case of a postmenopausal woman, who presented with complaints of postmenopausal bleeding. Imaging revealed a thickened endometrium. Histopathological examination of the endometrial sampling suggested invasive carcinoma with extensive squamous differentiation, raising a differential diagnosis between cervical and endometrial origin. The patient underwent staging laparotomy with total abdominal hysterectomy with pelvic lymphadenectomy. Final histopathological examination confirmed the diagnosis of endometrioid carcinoma with squamous differentiation with involvement of bilateral fallopian tubes in the absence of myometrial invasion. Conclusion-This case highlights the diagnostic challenge posed by squamous differentiation in endometrial carcinoma and demonstrates an unusual pattern of tumor spread to the fallopian tubes without myometrial invasion. Recognition of such atypical presentations is essential for accurate diagnosis, staging, and management.