Combinatorial effect of Ficus carica latex and olive oil on induced oral squamous cell carcinoma
DOI:
https://doi.org/10.64149/J.Carcinog.24.1s.90-100Keywords:
HBP carcinoma, fig latex, EVOOAbstract
Abstract: The present investigation was designed to assess the protective capabilities of Ficus carica (fig) extract and olive oil, administered individually and in combination, as potent natural antiproliferative agents against the adverse effects of DMBA on the HBP.
Material and methods: Fifty five-week-old male Syrian hamsters weighing between 80 and 120 grams were split up into five groups of ten hamsters within every group: GI: left untreated, GII: 7, 12-dimethyl benz[a]anthracene (DMBA) applied topically only on three occasions per week during 14 weeks at a concentration of 0.5% in liquid paraffin, GIII: DMBA (0.5% in liquid paraffin) applied topically on three occasions per week during 14-week plus oral fig latex (50 g lyophilized fig latex in 50 ml distilled water at a dosage of 1000 mg/ml shortly prior to experimental usage). GIV: DMBA (0.5% in liquid paraffin) used topically on three occasions per week over 14-week plus oral EVOO alone (7.6 ml /kg b.w by oral
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gavage, before and/or after DMBA application. GV: DMBA applied topically (0.5% in liquid paraffin, three occasions per week during 14 weeks) alongside oral fig latex and EVOO administration using dosages and administration techniques comparable to those used in individual therapies. The Qur'anic proportion of one fig to seven olives served as the basis for the specific dosages for each fig extract and olive oil.
Results: The current research findings demonstrated that fig latex and EVOO had a positive regression impact on the growth of tumors. The combination of fig latex and EVOO significantly decreased the occurrence of OSCC (oral squamous cell carcinoma) from 100% to 0%. According to the immunohistochemical study, fig latex and EVOO significantly reduced the expression of the antiproliferative marker PCNA in comparison to GII. Such findings highlighted the chemopreventive potential of fig latex and EVOO, suggesting their roles in inhibiting tumor growth and inducing apoptosis in oral cancer cells.
Conclusion: This study underscores the value of natural dietary components in cancer prevention and supports the further exploration of fig latex and EVOO as novel, safe, and effective therapeutic agents for oral malignancies..
