Synthesis, characterization and in vitro α-amylase inhibition potential of novel benzimidazole derivatives.

Abstract

Diabetes has become one of the foremost health concerns around the world, particularly in developing nations. By 2030, highest count of people encountering diabetes are anticipated to live in these areas. The amount of persons suffering from diabetes in India has grown dramatically. Estimates say that the number of cases would upsurge from 31.4 million in 2000 to 79.4 million by 2030, with urban populations having far higher rates than rural populations. This project aimed to synthesized and evaluate new benzimidazole derivatives as possible anti-diabetic drugs, focusing on their ability to block α-amylase. Using a simple two-step synthetic technique, benzimidazole derivatives were prepared and their properties were studied using spectral methods. The synthesized derivatives blocked α-amylase to different degrees, and a few of them worked as well as the conventional inhibitor acarbose. The results show that changing the structure at the 1-position of the benzimidazole nucleus affects the biological potency, with some substitutions making the inhibitory effects stronger. This study adds to the existing knowledge about benzimidazole derivatives as possible treatments for diabetes and lays the groundwork for more research and development in this area.