Microbiological Profile, Antibiotic Sensitivity Pattern, and Maternal Outcomes in Obstetric Patients with Sepsis and Septic Shock: A Prospective Observational Study in a Tertiary Care Hospital
DOI:
https://doi.org/10.64149/J.Carcinog.24.10s.154-161Keywords:
Obstetric sepsis, septic shock, microbiological profile, antibiotic sensitivity, maternal outcomes, Sohar Hospital Sohar, OmanAbstract
Background: Sepsis and septic shock are the most common causes of maternal morbidity and mortality, especially in developing nations where antimicrobial resistance and late diagnosis complicate treatment. It is essential to learn the microbial spectrum, susceptibility to antibiotics, and outcomes related to maternal care in order to make informed care and minimize morbidity and mortality.
Objective: To identify the microbiological profile, the pattern of antibiotic sensitivity, and maternal outcomes in obstetric patients with sepsis and septic shock at Sohar Hospital Sohar, Oman.
Methods: The study is a prospective cross-sectional study to be carried out in the department of obstetrics and gynecology during the period from February 2020 to July 2020. Sixty obstetric patients who fit the diagnostic criteria of sepsis or septic shock were involved. Culture of blood, urine, and vaginal samples was performed, and identification of the isolates was performed using standard microbiological methods. The Kirby-Bauer disc diffusion test was used to determine the antibiotic sensitivity. SPSS version 26 was used to analyze the data.
Results: Gram-negative bacteria were the most common (73.3%), with Escherichia coli (30%) and Klebsiella pneumoniae (20%) as the most common organisms. Cephalosporins (70%) showed high resistance, and carbapenems and aminoglycosides were the most effective. The overall outcome was a 60% recovery rate and a 6.7% mortality rate, mainly due to multidrug-resistant infections.
Conclusion: Gram-negative pathogens are the greatest cause of obstetric sepsis at Sohar Hospital Sohar, Oman. The prevalence of high antibiotic resistance demonstrates the importance of strong infection control, regular therapy based on cultures, and antibiotic stewardship to enhance maternal outcomes and decrease the mortality related to sepsis
