Study of skeletal muscle relaxant effect of baclofen loaded transdermal patch in mice

Abstract

Treatment of musculoskeletal pain is a challenging condition affecting approximately 47% of the general population. The objective of this investigation was to prepare transdermal patches of baclofen and assess its skeletal muscle relaxant potential. The patches were prepared using HPMC-Eudragit or Eudragit-Ethylcellulose as the polymeric matrix. The patches were found to have significant skeletal muscle relaxant action compared to control group. The patches prepared using Eudragit-Ethylcellulose were able to produce significant effect compared to pure drug baclofen. The study led us to conclude that transdermal patch is an effective alternative to oral delivery of baclofen, helpful in reducing the dose and associated side effects of the drug.