Systemic Sclerosis: An Oral Pathologist Perspectives

Abstract

Systemic sclerosis (SSc) also known as scleroderma is an uncommon, complex, multisystem disorder of connective tissue. It presents with heterogenous clinical manifestations and is characterized by its chronic and progressive nature, often leading to significant disability and mortality. In the oral cavity, the progressive fibrosis appearances reminiscent of late stages of oral submucous fibrosis. Although like Oral submucous fibrosis, can be distinguished with clinical & immunological findings. This review highlights clinical features, gene involvement, overlapping syndrome, Differential diagnosis and management of SSc.