Effect of Cholesterol Concentration on Simvastatin Encapsulated Niosome Containing Span 60 and Span 80 as Surfactant

Abstract

Niosomes are a novel drug delivery system, where the drug is encapsulated in a bilayered vesicle of Non-ionic surfactant. Simvastatin is origin chemically by fermentation from Aspergillus terreus. It actsas an Antihyperlipidemic. It hydrolyzes to create beta, delta, and dihydroxy acid, which structurally resembles HMG-CoA. Thus, for HMG-CoA reductase, hydrolyzed simvastatin competes with HMG-CoA. To improve in-vitro and well-in-vivo release and increase bioavailability, simvastatin niosomes are used. After the evaluation, it may be hypothesized that a formulation having a higher concentration of cholesterol may alter the physicochemical properties and in vitro release of the encapsulated drug molecule. It was also found that the formulation with half the concentration of cholesterol than the surfactant may give a smaller particle size of the vesicle system. Thus, it can be concluded that cholesterol has a significant effect on niosomes.