Gene- Gene And Protein -Protein Interactions In Triple Negative Breast Cancer Genes

Abstract

Six high frequency mutated proteins were identified as unique in TNBC, DNBC and SNBC and in genes BRCA1is found to be unique and highly mutated compared to others in TNBC where as EGFR is highly expressed in TNBC and FOXC1 is specific transcription factor associated with the TNBC and SOX10 is the marker for mesenchymal TNBC. CDK12 is specific to DNBC and GATA3 is specific to SNBC. AR (LAR Type) and KIT (Stem Like) specific and associated with TNBC. EGFR, Nestin, SOX10 and Vimentin are the proteins found uniquely in TNBC and GRB7 in DNBC and FOX A1 in SNBC.Online tools and databases like Gene mania, STRING and PINA are used for the study of Gene- Gene interactions and Protein-Protein interactions and protein coexpression and colocalization and the proteins sharing common signaling pathways. Vimentin found to coexpress with EGFR and SOX10 and Vimentin specifically coexpress with nestin. From the studies of gene- gene interactions BRCA1,GRB7,GATA3 and AR show physical interactions and share common interacting partners in signalling pathways.