Design In Silico Docking And Polymeric Micelle Formulation Of New Benzothiazole Analogs As Antimicrobial Agents

Abstract

The emergence of multidrug-resistant pathogens necessitates the development of novel antimicrobial agents. Benzothiazole derivatives exhibit promising biological activity due to their versatile structural scaffold. In this study, new benzothiazole analogs were designed and evaluated for their binding affinity against bacterial target proteins through in silico docking studies. To enhance solubility, stability, and delivery efficiency, these compounds were incorporated into polymeric micelles. Docking results demonstrated significant binding interactions, indicating potential antimicrobial efficacy. The polymeric micelles displayed uniform particle size and high encapsulation efficiency, suggesting improved bioavailability. This integrative approach provides a platform for further experimental validation of benzothiazole analogs as effective antimicrobial agents.