Patel Viral1, K Pavithran2, K Beena3, Ajil Shaji4, DK Vijaykumar5
1Department of Gynecological Oncology, Amrita Institute of Medical Science, Kochi, Kerala, India
2Department of Medical Oncology, Amrita Institute of Medical Science, Kochi, Kerala, India
3Department of Radiation Oncology, Amrita Institute of Medical Science, Kochi, Kerala, India
4Department of Cancer Registry, Amrita Institute of Medical Science, Kochi, Kerala, India
5Amrita Centre for Breast Diseases, Amrita Institute of Medical Science, Kochi, Kerala, India
DOI: 10.4103/jcar.JCar_26_20
ABSTRACT
INTRODUCTION: Breast cancer is the most frequently diagnosed cancer among women in India; however, there are no studies addressing long-term survival (10 years and above). This study sought to evaluate long-term oncological outcome among women with breast cancer treated with a curative intent.
MATERIALS AND METHODS: This is a retrospective cohort analysis of 1301 breast cancer patients of all stages who had received primary treatment with curative intent from 2004 to 2010 at a single cancer institution of India.
RESULTS: A total of 1301 breast cancer patients were available for final analysis. The median age was 51 years (range, 21–86 years). 70.25% of the patients had early breast cancer (EBC), 21.9% had locally advanced breast cancer, and 7.85% of the patients with de novo metastatic disease also underwent surgery. 56.5% of the patients had hormone-sensitive tumors, human epidermal growth factor receptor 2 over expression was seen in 17%, and triple-negative tumors accounted for 26.2% of the patients. The 5- and 10-year overall survival (OS) of the entire cohort was 79% and 66%, and the 5- and 10-year breast cancer-specific survival (BCSS) was 79% and 70%, respectively. OS and BCSS were 51% and 58%, respectively, at 15-year follow-up after primary cancer treatment. On multivariate analysis, the factors associated with prolonged survival were age ≤50 years, EBC, and treatment during the later period (2008–2010).
CONCLUSION: Difference between OS and BCSS was found to have an increasing trend during 10–15-year follow-up, the difference being 4% at 10 years and 7% at 15 years. Age ≤50 years, early-stage disease at presentation, and primary cancer treatment in later years (2008–2010) were favorable predictors for 10-year survival.
Keywords: 10 years, breast cancer, India, long-term survival, oncological outcome after treatment.