Antiangiogenic mechanisms and factors in breast cancer treatment

Jessica M CastaƱeda-Gill1, Jamboor K Vishwanatha2
1Department of Molecular and Medical Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA
2Department of Molecular and Medical Genetics, Graduate School of Biomedical Sciences; Institute for Cancer Research?, Texas Center for Health Disparities, University of North Texas Health Science Center, Fort Worth, TX, USA
DOI: 10.4103/1477-3163.176223

ABSTRACT

Breast cancer is known to metastasize in its latter stages of existence. The different angiogenic mechanisms and factors that allow for its progression are reviewed in this article. Understanding these mechanisms and factors will allow researchers to design drugs to inhibit angiogenic behaviors and control the rate of tumor growth.

Keywords: Angiogenesis, breast cancer, metastasis, therapy, tumor vasculature