Lauren Peirce Carcas
Department of Hematology and Oncology, Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.
Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Despite an overall decline in incidence over the last several decades, gastric cancer remains the fourth most common type of cancer and is the second leading cause of cancer-related death worldwide. This review aims to discuss the global distribution of the disease and the trend of decreasing incidence of disease, delineate the different pathologic subtypes and their immunohistochemical (IHC) staining patterns and molecular signatures and mutations, explore the role of the pathogen H. pylori in tumorgenesis, discuss the increasing incidence of the disease in the young, western populations and define the role of biologic agents in the treatment of the disease.
Keywords: Biologic targeted therapy, diffuse subtype, gastric cancer, Helicobacter pylori, intestinal subtype