Haneen S. Al-Kurdi 1, Shimal Y. Abdul-Hadi 2
1Department of Biology, College Education for Pure Since, University of Mosul/Iraq.
2Department of Biology, College Education for Pure Since, University of Mosul/Iraq
ABSTRACT
The extraction process involved obtaining Taxol from the fruiting bodies of Schizophyllum Radiatum, a fungal species known for its taxane-producing capabilities. The study employed various analytical techniques, including chromatography and spectroscopy, to confirm the purity and identify the chemical profile of the extracted Taxol. In vitro experiments were conducted to evaluate the cytotoxicity of Taxol against SKOV-3 cells, employing standard assays to assess cell viability, apoptosis induction, and cell cycle alterations. The results revealed a dose-dependent reduction in cell viability, indicating the potential of Taxol from Schizophyllum Radiatum as an anti-cancer agent against ovarian cancer cells. Furthermore, mechanistic studies were undertaken to elucidate the underlying pathways involved in the anti-cancer activity. The study investigated the impact of Taxol on key molecular targets associated with cell survival and apoptosis, providing insights into its potential as a targeted therapeutic agent.
Keywords:Human health care, Death rates, Pneumonia, tuberculosis, influenza.