Tameka A Bailey1, Haitao Luan2, Robert J Clubb1, Mayumi Naramura3, Vimla Band3, Srikumar M Raja4, Hamid Band5
1Eppley Institute for Research in Cancer and Allied Diseases, College of Medicine, University of Nebraska Medical Center, 985950 Nebraska Medical Center Omaha, NE, USA.
2Eppley Institute for Research in Cancer and Allied Diseases; Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, 985950 Nebraska Medical Center Omaha, NE, USA.
3Eppley Institute for Research in Cancer and Allied Diseases; Department of Genetics, Cell Biology and Anatomy, College of Medicine; UNMC-Eppley Cancer Center, University of Nebraska Medical Center, 985950 Nebraska Medical Center Omaha, NE, USA.
4Eppley Institute for Research in Cancer and Allied Diseases, College of Medicine; UNMC-Eppley Cancer Center, University of Nebraska Medical Center, 985950 Nebraska Medical Center Omaha, NE, USA.
5Eppley Institute for Research in Cancer and Allied Diseases, College of Medicine; Department of Genetics, Cell Biology and Anatomy, College of Medicine; Department of Biochemistry and Molecular Biology, College of Medicine; Department of Pathology and Microbiology, College of Medicine; Department of Pharmacology and Experimental Neuroscience, College of Medicine; UNMC-Eppley Cancer Center, University of Nebraska Medical Center, 985950 Nebraska Medical Center Omaha, NE, USA.
DOI: 10.4103/1477-3163.90442
Introduction
Top ErbB2 (Her2/Neu) is a member of the ErbB family of receptor tyrosine kinases (RTKs), which includes EGFR (ErbB1, Her1), ErbB3 (Her3), and ErbB4 (Her4). ErbB2 is the preferred dimerization partner for ErbB1, 3, and 4 following growth factor stimulation by ligands such as EGF, TGF-α, and amphiregulin (for EGFR) or Heregulins/Neuregulins (for ErbB3/4). [1] Oncogenic signaling by ErbB2 involves a sustained activation of a number of pathways, including the Ras-Raf-MAPK pathway, which contributes to enhanced cellular proliferation, and the PI3K-Akt pathway, which imparts cell survival among other important biological effects.Read More…