Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats

Gayle A Orner1, Bill D Roebuck2, Roderick H Dashwood3, George S Bailey3
1Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
2Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH, USA
3Linus Pauling Institute, Oregon State University; Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR, USA
DOI: 10.1186/1477-3163-5-6


Chlorophyllin (CHL) is a promising chemopreventive agent believed to block cancer primarily by inhibiting carcinogen uptake through the formation of molecular complexes with the carcinogens. However, recent studies suggest that CHL may have additional biological effects particularly when given after the period of carcinogen treatment. This study examines the post-initiation effects of CHL towards aflatoxin B1 (AFB 1 )-induced preneoplastic foci of the liver and colon. The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB 1 -induced foci of the liver and colons of rats. Read more…