REVIEW ARTICLE
Year : 2016  |  Volume : 15  |  Issue : 1  |  Page : 3

The well-accepted notion that gene amplification contributes to increased expression still remains, after all these years, a reasonable but unproven assumption


1 Animal Facilities, Shandong Academy of Pharmaceutical Sciences, Ji'nan, Shandong 250101, USA
2 Hormel Institute, University of Minnesota, Austin, MN 55912, USA
3 Laboratory of Cell and Molecular Biology, Cancer Institute, Chinese Academy of Medical Science, Beijing 100021, China
4 Department of Pathology, Guizhou Medical University Hospital, Guizhou, Guiyang 550004, China

Correspondence Address:
Dezhong Joshua Liao
Department of Pathology, Guizhou Medical University Hospital, Guizhou, Guiyang 550004
China
Ningzhi Xu
Laboratory of Cell and Molecular Biology, Cancer Institute, Chinese Academy of Medical Science, Beijing 100021
China
Yuping Jia
Animal Facilities, Shandong Academy of Pharmaceutical Sciences, Ji'nan, Shandong 250101
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1477-3163.182809

"Gene amplification causes overexpression" is a longstanding and well-accepted concept in cancer genetics. However, raking the whole literature, we find only statistical analyses showing a positive correlation between gene copy number and expression level, but do not find convincing experimental corroboration for this notion, for most of the amplified oncogenes in cancers. Since an association does not need to be an actual causal relation, in our opinion, this widespread notion still remains a reasonable but unproven assumption awaiting experimental verification.


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