REVIEW ARTICLE
Year : 2011  |  Volume : 10  |  Issue : 1  |  Page : 5

Wnt signaling and colon carcinogenesis: Beyond APC


1 Department of Microbiology and Molecular Genetics, University of California, Irvine, USA
2 Tisch Cancer Institute, Mt. Sinai School of Medicine, New York, USA

Correspondence Address:
Rani Najdi
Department of Microbiology and Molecular Genetics, University of California, Irvine
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1477-3163.78111

Activation of the Wnt signaling pathway via mutation of the adenomatous polyposis coli gene (APC) is a critical event in the development of colon cancer. For colon carcinogenesis, however, constitutive signaling through the canonical Wnt pathway is not a singular event. Here we review how canonical Wnt signaling is modulated by intracellular LEF/TCF composition and location, the action of different Wnt ligands, and the secretion of Wnt inhibitory molecules. We also review the contributions of non-canonical Wnt signaling and other distinct pathways in the tumor micro environment that cross-talk to the canonical Wnt pathway and thereby influence colon cancer progression. These 'non-APC' aspects of Wnt signaling are considered in relation to the development of potential agents for the treatment of patients with colon cancer. Regulatory pathways that influence Wnt signaling highlight how it might be possible to design therapies that target a network of signals beyond that of APC and β-catenin.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed19379    
    Printed562    
    Emailed8    
    PDF Downloaded206    
    Comments [Add]    
    Cited by others 41    

Recommend this journal