REVIEW ARTICLE
Year : 2011  |  Volume : 10  |  Issue : 1  |  Page : 20

Androgen receptor signaling in prostate cancer development and progression


Department of Urology, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA

Correspondence Address:
Donald J Tindall
Department of Urology, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1477-3163.83937

The androgen receptor (AR) signaling axis plays a critical role in the development, function and homeostasis of the prostate. The classical action of AR is to regulate gene transcriptional processes via AR nuclear translocation, binding to androgen response elements on target genes and recruitment of, or crosstalk with, transcription factors. Prostate cancer initiation and progression is also uniquely dependent on AR. Androgen deprivation therapy remains the standard of care for treatment of advanced prostate cancer. Despite an initial favorable response, almost all patients invariably progress to a more aggressive, castrate-resistant phenotype. Considerable evidence now supports the concept that development of castrate-resistant prostate cancer (CRPC) is causally related to continued transactivation of AR. Understanding the critical events and complexities of AR signaling in the progression to CRPC is essential in developing successful future therapies. This review provides a synopsis of AR structure and signaling in prostate cancer progression, with a special focus on recent findings on the role of AR in CRPC. Clinical implications of these findings and potential directions for future research are also outlined.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed42100    
    Printed838    
    Emailed27    
    PDF Downloaded2488    
    Comments [Add]    
    Cited by others 51    

Recommend this journal